Valerie G Brunton Selected Research

AZD-0424

1/2022

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment.

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Valerie G Brunton Research Topics

Disease

52	Neoplasms (Cancer) 07/2022 - 06/2004
17	Breast Neoplasms (Breast Cancer) 01/2022 - 10/2009
9	Neoplasm Metastasis (Metastasis) 01/2018 - 01/2005
8	Colonic Neoplasms (Colon Cancer) 09/2008 - 08/2002
4	Carcinogenesis 01/2018 - 02/2009
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/2017 - 02/2009
2	Lobular Carcinoma 10/2021 - 10/2018
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 12/2020 - 02/2012
2	Prostatic Neoplasms (Prostate Cancer) 01/2018 - 05/2009
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2017 - 08/2013
2	Papilloma (Papillomatosis) 12/2012 - 02/2009
2	Carcinoma (Carcinomatosis) 12/2006 - 02/2005
2	autosomal recessive 1 Spinocerebellar ataxia 01/2006 - 12/2004
1	Triple Negative Breast Neoplasms 01/2022
1	Bites and Stings (Sting) 01/2019
1	Hemangiosarcoma (Angiosarcoma) 01/2019
1	Poikiloderma of Kindler 01/2019
1	Sarcoma (Soft Tissue Sarcoma) 01/2019
1	Lymphoma (Lymphomas) 01/2019
1	Melanoma (Melanoma, Malignant) 12/2018
1	Hypersensitivity (Allergy) 01/2018
1	Kidney Neoplasms (Kidney Cancer) 01/2017
1	Metaplasia 08/2013
1	Bone Diseases (Bone Disease) 05/2013
1	Osteolysis 05/2013
1	Residual Neoplasm 02/2012
1	Osteosarcoma (Osteogenic Sarcoma) 07/2011

Drug/Important Bio-Agent (IBA)

14	src-Family KinasesIBA 01/2022 - 06/2004
12	Phosphotransferases (Kinase)IBA 01/2022 - 10/2004
10	Focal Adhesion Protein-Tyrosine KinasesIBA 07/2022 - 02/2005
10	Pharmaceutical PreparationsIBA 01/2022 - 10/2004
10	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2004
9	IntegrinsIBA 01/2018 - 08/2002
7	Cadherins (E-Cadherin)IBA 10/2018 - 08/2002
6	Dasatinib (BMS 354825)FDA Link 08/2013 - 12/2006
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022 - 09/2011
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2022 - 01/2011
3	Biomarkers (Surrogate Marker)IBA 11/2020 - 12/2006
3	Lapatinib (GW572016)FDA Link 02/2020 - 08/2014
3	human ERBB2 proteinIBA 03/2016 - 10/2009
2	Biological ProductsIBA 10/2021 - 01/2021
2	Estrogen Receptor alphaIBA 01/2021 - 11/2020
2	Transcription Factors (Transcription Factor)IBA 01/2017 - 01/2017
2	AZD 8931IBA 03/2016 - 02/2016
2	LigandsIBA 09/2015 - 05/2013
2	Tyrosine Kinase InhibitorsIBA 05/2013 - 07/2011
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2006 - 10/2004
1	Insulin-Like Growth Factor I (IGF-1)IBA 02/2022
1	integrin-linked kinaseIBA 01/2022
1	bosutinibIBA 01/2022
1	AZD-0424IBA 01/2022
1	UbiquitinIBA 11/2021
1	Estrogen ReceptorsIBA 10/2021
1	Fulvestrant (Faslodex)FDA Link 01/2021
1	ponatinibIBA 12/2020
1	IronIBA 02/2020
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2019
1	DNA (Deoxyribonucleic Acid)IBA 01/2019
1	cadherin 5IBA 01/2019
1	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 01/2019
1	nifuroxazide (Akabar)IBA 12/2018
1	ProdrugsIBA 12/2018
1	EnzymesIBA 12/2018
1	Aldehyde DehydrogenaseIBA 12/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2018
1	Antineoplastic Agents (Antineoplastics)IBA 10/2018
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2018
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2018
1	RibonucleotidesIBA 01/2018
1	TenascinIBA 01/2018
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2018
1	Ribonucleases (Ribonuclease)IBA 01/2018
1	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 01/2018
1	Insulin-Like Growth Factor Binding Protein 3IBA 10/2017
1	Protein Isoforms (Isoforms)IBA 01/2017
1	Docetaxel (Taxotere)FDA Link 01/2017
1	Axl Receptor Tyrosine KinaseIBA 01/2016
1	PND 1186IBA 09/2015
1	ChemokinesIBA 09/2015
1	AntigensIBA 09/2015
1	CytokinesIBA 09/2015
1	Lysophosphatidic Acid ReceptorsIBA 10/2014
1	GTP-Binding Proteins (G-Protein)IBA 10/2014
1	Trastuzumab (Herceptin)FDA Link 08/2014
1	Fluorouracil (Carac)FDA LinkGeneric 01/2014
1	PalladiumIBA 01/2014
1	Insulin-Like PeptidesIBA 05/2013
1	IGF Type 1 Receptor (IGF 1 Receptor)IBA 05/2013
1	Macrophage Colony-Stimulating FactorIBA 05/2013
1	Insulin (Novolin)FDA Link 05/2013
1	Phorbol EstersIBA 12/2012
1	matriptaseIBA 01/2012
1	lenvatinibIBA 07/2011
1	Fluorescent Dyes (Fluorescent Probes)IBA 07/2011
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 07/2011
1	ActomyosinIBA 06/2011
1	CarcinogensIBA 06/2011

Therapy/Procedure

16	Therapeutics 01/2022 - 05/2009
2	Drug Therapy (Chemotherapy) 01/2017 - 10/2004
1	Lasers (Laser) 02/2022